Single electrode dynamic clamp with StdpC
نویسندگان
چکیده
منابع مشابه
Single electrode dynamic clamp with StdpC
Dynamic clamp is a powerful approach for electrophysiological investigations allowing researchers to introduce artificial electrical components into target neurons to simulate ionic conductances, chemical or electrotonic inputs or connections to other cells. Due to the rapidly changing and potentially large current injections during dynamic clamp, problematic voltage artifacts appear on the ele...
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With the advancement of computer technology many novel uses of dynamic clamp have become possible. We have added new features to our dynamic clamp software StdpC ("Spike timing-dependent plasticity Clamp") allowing such new applications while conserving the ease of use and installation of the popular earlier Dynclamp 2/4 package. Here, we introduce the new features of a waveform generator, free...
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The use of a discontinuous single electrode voltage-clamp (dSEVC) offers an attractive alternative to the patch-clamp technique, since whole-cell measurements can be performed with a single sharp electrode. Comparison of current-voltage relations, however, revealed a weaker voltage dependence of channels measured with the dSEVC compared to patch clamp. The accuracy of the dSEVC was tested on Vi...
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The single-electrode voltage-clamp technique requires sharp glass-capillary microelectrodes, whose electrical properties often limit the capabilities of the recording system. Here, we describe a rapid and simple way of coating fine microelectrodes with Dricote and Vaseline that improves their performance during voltage-clamp. The coating prevented clogging of the tips, improved the capacitance ...
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Results 712 (male 77.5%) patients were operated on, with 609 (85.54%) being isolated CABG and 103 (14.46%) combined CABG with AVR. Average age in isolated CABG and combined groups were 66 and 73 years respectively. Average additive EuroScores were 3.5 and 7.29. 21.6% cases were performed by trainee or staff grade surgeon. In hospital mortality was 0.16% in isolated CABG and 0% in CABG with AVR ...
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ژورنال
عنوان ژورنال: Journal of Neuroscience Methods
سال: 2012
ISSN: 0165-0270
DOI: 10.1016/j.jneumeth.2012.08.003